Mine is basically set up like what it looked like in DVD Profiler 2.x (Filter/List left, then General/Features(Video, Audio/Overview followed by Crew/Cast and on the right are Front/Back scans). I was so used to it that I went that route and then never bothered to experiment...
It's for 1920x1200 though, so you would have to make some subtle adjustments to some widths, I guess. However, I believe during the first load DVD Profiler will do some adjustments automaticaly without messing it up. If you want to try it...